Compound Detail
CHEMBL1610433
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Basic Information
| ChEMBL ID | CHEMBL1610433 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UMAOLLLRFPHFBM-LGMDPLHJSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
460.6
MW (Da)
3.84
ALogP
8
HBA
1
HBD
75.9
PSA (Ų)
0.35
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.8
IC50 2 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 26S proteasome non-ATPase regulatory subunit 14 CHEMBL2007629 | IC50 | 7.05 | 7.05 | 90.0 | 1 |
| Prothrombin CHEMBL4471 | IC50 | 6.83 | 6.83 | 148.0 | 1 |
| Endoribonuclease toxin MazF CHEMBL1795096 | EC50 | 4.8 | 4.635 | 16000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 26S proteasome non-ATPase regulatory subunit 14 | IC50 | = | 90.0 | nM | 7.05 | PUBCHEM_BIOASSAY: Dose response confirmation of uHTS RPN11 inhibitor hits in a F... | - |
| Prothrombin | IC50 | = | 148.0 | nM | 6.83 | PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a ... | - |
| Endoribonuclease toxin MazF | EC50 | = | 16000.0 | nM | 4.8 | PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... | - |
| Endoribonuclease toxin MazF | EC50 | = | 34200.0 | nM | 4.47 | PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... | - |
Data from ChEMBL 36 via Core Engine