Prothrombin · SINGLE PROTEIN · Bos taurus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P00735. Use UniProt P00735 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00735 as the stable identity anchor, then attach disease evidence before program review.
Prothrombin
Review this target as Prothrombin, mapped to UniProt P00735. Sequence length is 625 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prothrombin as ChEMBL target CHEMBL4471, mapped to UniProt P00735. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Prothrombin is the right protein anchor across sources, using UniProt P00735 as the stable mapping.
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| Preferred Name | Prothrombin |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P00735 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prothrombin |
| UniProt Accession | P00735 |
| Component Type | Protein |
| Sequence Length | 625 aa |
Prothrombin
Review this target as Prothrombin, mapped to UniProt P00735. Sequence length is 625 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3343301 | 10.02 | Ki | 0.096 | Preclinical |
| CHEMBL3219101 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL3219100 | 9.1 | Ki | 0.8 | Preclinical |
| CHEMBL3219086 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL3219078 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL3219076 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL353818 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL269206 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL7962 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL347158 | 8.83 | Ki | 1.47 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 68 | 590 | 6.2 |
| cell-free format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 511 | 4.8 |
| cell-free format | 1 | 13 | 4.9 |