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Evidence Snapshot

Prothrombin

CHEMBL4471 SINGLE PROTEIN Bos taurus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:06Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4471
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prothrombin as ChEMBL target CHEMBL4471, mapped to UniProt P00735. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prothrombin
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL4471
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P00735
Prothrombin
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Prothrombin matters

As of 2026-09-14

Prothrombin is reviewed as Prothrombin (UniProt P00735); the current evidence base includes 1 approved drug, 1550 compounds, and 78 assays, with lead potency reaching pChEMBL 10.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 1550 compounds, and 78 assays for this target. The dominant activity type is IC50. CHEMBL3343301 is the current potency anchor at pChEMBL 10.0.

Use CHEMBL3343301 as the tractability anchor when discussing potency (pChEMBL 10.0).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 10.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Prothrombin matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P00735, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1550
Total Compounds
78
Total Assays
1
Approved Drugs
IC50: 711.0, KI: 557.0, EC50: 2.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3343301
 10.0 Ki —
No preferred name
CHEMBL3219101
 9.7 Ki —
No preferred name
CHEMBL3219100
 9.1 Ki —
No preferred name
CHEMBL3219076
 9.0 Ki —
No preferred name
CHEMBL3219078
 9.0 Ki —

Approved Drugs

Structure Compound First Approval
ARGATROBAN
CHEMBL1166
 2000
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:06Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4471