Assay Detail
Functional
CHEMBL1964096
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PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay. (Class of assay: confirmatory)
396
Total Activities
396
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 396 | 4.46 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1610433 | — | — | 1 | 6.83 |
| CHEMBL1548928 | — | — | 1 | 6.33 |
| CHEMBL1471965 | — | — | 1 | 6.28 |
| CHEMBL1986889 | — | — | 1 | 6.25 |
| CHEMBL1333181 | — | — | 1 | 5.86 |
| CHEMBL1991303 | — | — | 1 | 5.79 |
| CHEMBL1984584 | — | — | 1 | 5.69 |
| CHEMBL1974063 | — | — | 1 | 5.59 |
| CHEMBL1491016 | — | — | 1 | 5.54 |
| CHEMBL2005518 | — | — | 1 | 5.42 |
| CHEMBL1706207 | — | — | 1 | 5.32 |
| CHEMBL1452158 | — | — | 1 | 5.29 |
| CHEMBL1313324 | — | — | 1 | 5.29 |
| CHEMBL1345911 | — | — | 1 | 5.19 |
| CHEMBL1587502 | — | — | 1 | 5.17 |
| CHEMBL2003445 | — | — | 1 | 5.15 |
| CHEMBL1425576 | — | — | 1 | 5.14 |
| CHEMBL1558644 | — | — | 1 | 5.11 |
| CHEMBL1347610 | — | — | 1 | 5.11 |
| CHEMBL1876111 | — | — | 1 | 5.08 |
| CHEMBL1421745 | — | — | 1 | 5.08 |
| CHEMBL1560833 | — | — | 1 | 5.01 |
| CHEMBL1983530 | — | — | 1 | 5.01 |
| CHEMBL1534006 | — | — | 1 | 5.00 |
| CHEMBL1492565 | — | — | 1 | 4.99 |
| CHEMBL2003808 | — | — | 1 | 4.97 |
| CHEMBL1422472 | — | — | 1 | 4.94 |
| CHEMBL1458593 | — | — | 1 | 4.94 |
| CHEMBL1727678 | — | — | 1 | 4.93 |
| CHEMBL244645 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1610433 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL1548928 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL1471965 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL1986889 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL1333181 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL1991303 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL1984584 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL1974063 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL1491016 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2005518 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL1706207 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL1313324 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL1452158 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL1345911 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL1587502 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL2003445 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL1425576 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL1347610 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL1558644 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL1421745 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL1876111 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL1560833 | — | IC50 | = | 9790.0 | nM | 5.01 |
| CHEMBL1983530 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL1534006 | — | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL1492565 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2003808 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1422472 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1458593 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1727678 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL244645 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL1320535 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL1888496 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1480510 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1497731 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL129208 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL2007227 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1552672 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1361889 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1556684 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1384373 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1518982 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1612291 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1518206 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1501743 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1990774 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1564058 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL1705518 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1873140 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1303333 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL1569092 | — | IC50 | = | 19500.0 | nM | 4.71 |