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Assay Detail

CHEMBL1614294

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). (Class of assay: confirmatory) [Related pubchem assays: 1963 (Summary AID.), 1962 (Primary screen (TPT1 inhibitors).), 2153 (Counterscreen (RNase inhibitors).), 2149 (Confirmation screen (TPT1 inhibitors).)]
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans SC5314
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Likely tRNA 2'-phosphotransferase (CHEMBL1293308)
Type SINGLE PROTEIN
Organism Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.48 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1497651 1 6.85
CHEMBL1431007 1 6.56
CHEMBL6246 ELLAGIC ACID 2.0 1 6.27
CHEMBL1590946 CEFSULODIN SODIUM -1.0 1 5.77
CHEMBL1455226 1 5.61
CHEMBL1988133 1 5.45
CHEMBL1460470 1 5.36
CHEMBL1458563 1 5.26
CHEMBL1464805 1 5.23
CHEMBL1329141 1 5.10
CHEMBL1517227 1 4.97
CHEMBL1401747 1 4.86
CHEMBL257359 1 4.69
CHEMBL1416439 1 4.68
CHEMBL1322297 1 -
CHEMBL1611294 1 -
CHEMBL3197767 1 -
CHEMBL1990545 1 -
CHEMBL1517376 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1497651 IC50 = 142.1 nM 6.85
CHEMBL1431007 IC50 = 274.94 nM 6.56
CHEMBL6246 ELLAGIC ACID IC50 = 540.68 nM 6.27
CHEMBL1590946 CEFSULODIN SODIUM IC50 = 1686.0 nM 5.77
CHEMBL1455226 IC50 = 2439.0 nM 5.61
CHEMBL1988133 IC50 = 3548.0 nM 5.45
CHEMBL1460470 IC50 = 4402.0 nM 5.36
CHEMBL1458563 IC50 = 5551.0 nM 5.26
CHEMBL1464805 IC50 = 5930.0 nM 5.23
CHEMBL1329141 IC50 = 8006.0 nM 5.10
CHEMBL1517227 IC50 = 10682.0 nM 4.97
CHEMBL1401747 IC50 = 13977.0 nM 4.86
CHEMBL257359 IC50 = 20491.0 nM 4.69
CHEMBL1416439 IC50 = 20824.0 nM 4.68
CHEMBL1322297 IC50 > 55688.0 nM -
CHEMBL1611294 IC50 > 55688.0 nM -
CHEMBL3197767 IC50 > 55688.0 nM -
CHEMBL1990545 IC50 > 55688.0 nM -
CHEMBL1517376 IC50 > 2063.0 nM -