Compound Detail
CHEMBL1455226
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Basic Information
| ChEMBL ID | CHEMBL1455226 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BVLXBSJBJYWXAG-FMIVXFBMSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
312.4
MW (Da)
2.42
ALogP
4
HBA
1
HBD
62.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.61
EC50 1 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | EC50 | 6.15 | 6.15 | 710.0 | 1 |
| Likely tRNA 2'-phosphotransferase CHEMBL1293308 | IC50 | 5.61 | 5.61 | 2439.0 | 1 |
| Genome polyprotein CHEMBL1293305 | IC50 | 5.32 | 5.32 | 4780.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | EC50 | = | 710.0 | nM | 6.15 | PUBCHEM_BIOASSAY: Confirmation Dose Response screen for compounds that protect h... | - |
| Likely tRNA 2'-phosphotransferase | IC50 | = | 2439.0 | nM | 5.61 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Genome polyprotein | IC50 | = | 4780.0 | nM | 5.32 | PUBCHEM_BIOASSAY: TR-FRET-based biochemical high-throughput dose response assay ... | - |
Data from ChEMBL 36 via Core Engine