Assay Detail
ADMET
CHEMBL1614446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents. (Class of assay: confirmatory) [Related pubchem assays: 1511 (Primary HTS assay for 305616 compounds.)]
115
Total Activities
114
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 115 | 5.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1335175 | — | — | 1 | 8.00 |
| CHEMBL1493051 | — | — | 1 | 7.22 |
| CHEMBL1495832 | — | — | 1 | 7.00 |
| CHEMBL1982010 | — | — | 1 | 6.92 |
| CHEMBL1556270 | — | — | 1 | 6.82 |
| CHEMBL1964945 | — | — | 1 | 6.80 |
| CHEMBL3207466 | — | — | 1 | 6.75 |
| CHEMBL1323822 | — | — | 1 | 6.70 |
| CHEMBL1499073 | — | — | 1 | 6.68 |
| CHEMBL3194024 | — | — | 1 | 6.66 |
| CHEMBL3211804 | — | — | 1 | 6.64 |
| CHEMBL1531791 | — | — | 1 | 6.62 |
| CHEMBL1418045 | — | — | 1 | 6.62 |
| CHEMBL1328261 | — | — | 1 | 6.58 |
| CHEMBL1408585 | — | — | 1 | 6.54 |
| CHEMBL1991112 | — | — | 1 | 6.52 |
| CHEMBL1325818 | — | — | 1 | 6.46 |
| CHEMBL1418441 | — | — | 1 | 6.42 |
| CHEMBL1485892 | — | — | 1 | 6.42 |
| CHEMBL1493936 | — | — | 1 | 6.38 |
| CHEMBL1425875 | — | — | 1 | 6.36 |
| CHEMBL1389047 | — | — | 1 | 6.36 |
| CHEMBL1449916 | — | — | 1 | 6.34 |
| CHEMBL1331064 | — | — | 1 | 6.34 |
| CHEMBL1541582 | — | — | 1 | 6.30 |
| CHEMBL1304319 | — | — | 1 | 6.28 |
| CHEMBL1302442 | — | — | 1 | 6.26 |
| CHEMBL1428317 | — | — | 1 | 6.21 |
| CHEMBL1331485 | — | — | 1 | 6.18 |
| CHEMBL3190811 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1335175 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1493051 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1495832 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1982010 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1556270 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1964945 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3207466 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1323822 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1499073 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3194024 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3211804 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1418045 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1531791 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1328261 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1408585 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1991112 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1325818 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1485892 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1418441 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1493936 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1425875 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1389047 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1331064 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1449916 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1541582 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1304319 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1302442 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1428317 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1331485 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3190811 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1455226 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1432154 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1445436 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1540015 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1417328 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1600506 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1336298 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL1464647 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1520325 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1414766 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1362952 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1516792 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1490750 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1572330 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1585777 | — | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3194842 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL1572553 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL1518265 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1565328 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1447734 | — | EC50 | = | 1250.0 | nM | 5.90 |