Assay Detail
Binding
CHEMBL1048170
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Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.20 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570013 | — | — | 1 | 5.55 |
| CHEMBL81721 | TRIIODOPHENOL | — | 1 | 5.50 |
| CHEMBL60569 | — | — | 1 | 5.20 |
| CHEMBL570239 | — | — | 1 | 5.20 |
| CHEMBL570930 | — | — | 1 | 5.20 |
| CHEMBL576310 | — | — | 1 | 5.11 |
| CHEMBL378695 | — | — | 1 | 5.09 |
| CHEMBL1624 | LEVOTHYROXINE | 4.0 | 1 | 4.98 |
| CHEMBL571374 | — | — | 1 | 4.96 |
| CHEMBL326294 | ISATIN | — | 1 | - |
| CHEMBL227491 | — | — | 1 | - |
| CHEMBL576111 | — | — | 1 | - |
| CHEMBL570287 | — | — | 1 | - |
| CHEMBL571597 | — | — | 1 | - |
| CHEMBL571813 | — | — | 1 | - |
| CHEMBL570847 | — | — | 1 | - |
| CHEMBL577756 | — | — | 1 | - |
| CHEMBL576687 | — | — | 1 | - |
| CHEMBL570031 | — | — | 1 | - |
| CHEMBL572224 | — | — | 1 | - |
| CHEMBL572223 | — | — | 1 | - |
| CHEMBL571589 | — | — | 1 | - |
| CHEMBL571380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570013 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL81721 | TRIIODOPHENOL | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL60569 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL570239 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL570930 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL576310 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL378695 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1624 | LEVOTHYROXINE | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL571374 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL326294 | ISATIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL227491 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL576111 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL570287 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL571597 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL571813 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL570847 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL577756 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL576687 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL570031 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL572224 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL572223 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL571589 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL571380 | — | IC50 | > | 50000.0 | nM | - |