Compound Detail
CHEMBL81721
TRIIODOPHENOL Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL81721 |
| Name | TRIIODOPHENOL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VAPDZNUFNKUROY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
13
Publications
1
Known Names
Molecular Properties
471.8
MW (Da)
3.21
ALogP
1
HBA
1
HBD
20.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transthyretin CHEMBL3194 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transthyretin | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggr... | 19651509 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18160525 | 10.1128/aac.01019-07 | Cryptosporidium parvum | 13 |
| 19651509 | 10.1016/j.bmcl.2009.03.004 | Transthyretin | 3 |
| 3097319 | 10.1021/jm00162a006 | Transthyretin | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 3919186 | 10.1021/jm00381a018 | Transthyretin | 1 |
| 3100800 | 10.1021/jm00384a014 | Transthyretin | 1 |
| 3100800 | 10.1021/jm00384a014 | Thyroid hormone receptor | 1 |
| 3097319 | 10.1021/jm00162a006 | Unchecked | 1 |
| 18160525 | 10.1128/aac.01019-07 | HCT-8 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 34555615 | 10.1016/j.ejmech.2021.113847 | Transthyretin | 1 |
Data from ChEMBL 36 via Core Engine