Assay Detail
Functional
CHEMBL1048178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.19 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570015 | GSK-256066 | 2.0 | 1 | 11.00 |
| CHEMBL571381 | — | — | 1 | 10.50 |
| CHEMBL569791 | — | — | 1 | 10.00 |
| CHEMBL584327 | — | — | 1 | 9.30 |
| CHEMBL569556 | — | — | 1 | 8.90 |
| CHEMBL515240 | — | — | 1 | 8.20 |
| CHEMBL571171 | — | — | 1 | 7.80 |
| CHEMBL570029 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570015 | GSK-256066 | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL571381 | — | IC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL569791 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL584327 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL569556 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL515240 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL571171 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL570029 | — | IC50 | = | 15.85 | nM | 7.80 |