Compound Detail
CHEMBL571381
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1ccc(S(=O)(=O)c2cc(C)c3ncc(C(N)=O)c(Nc4cccc(OC)c4)c3c2)cc1
Basic Information
| ChEMBL ID | CHEMBL571381 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WRNCWDCGPYAYLC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
477.5
MW (Da)
4.24
ALogP
7
HBA
2
HBD
120.6
PSA (Ų)
0.41
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 10.7 | 10.7 | 0.0 | 1 |
| PBMC CHEMBL613107 | IC50 | 10.5 | 10.5 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 0.01995 | nM | 10.7 | Inhibition of human recombinant PDE4B by scintillation proximity assay | 19656678 |
| PBMC | IC50 | = | 0.03162 | nM | 10.5 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TN... | 19656678 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19656678 | 10.1016/j.bmcl.2009.04.012 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 19656678 | 10.1016/j.bmcl.2009.04.012 | PBMC | 1 |
Data from ChEMBL 36 via Core Engine