3',5'-cyclic-AMP phosphodiesterase 4B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q07343. Use UniProt Q07343 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q07343 as the stable identity anchor, then attach disease evidence before program review.
3',5'-cyclic-AMP phosphodiesterase 4B
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4B, mapped to UniProt Q07343. Sequence length is 736 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3',5'-cyclic-AMP phosphodiesterase 4B as ChEMBL target CHEMBL275, mapped to UniProt Q07343. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 3',5'-cyclic-AMP phosphodiesterase 4B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q07343 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3',5'-cyclic-AMP phosphodiesterase 4B |
| UniProt Accession | Q07343 |
| Component Type | Protein |
| Sequence Length | 736 aa |
3',5'-cyclic-AMP phosphodiesterase 4B
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4B, mapped to UniProt Q07343. Sequence length is 736 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL569791 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3287987 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL4744560 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL4794267 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3986586 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL3287739 | 10.8 | IC50 | 0.01585 | Preclinical |
| CHEMBL3287991 | 10.8 | IC50 | 0.01585 | Preclinical |
| CHEMBL3287995 | 10.8 | IC50 | 0.01585 | Preclinical |
| CHEMBL1830791 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL571381 | 10.7 | IC50 | 0.01995 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 209 | 1,563 | 7.3 |
| cell-based format | 90 | 450 | 6.5 |
| assay format | 33 | 483 | 6.7 |
| tissue-based format | 2 | 34 | 4.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 2 | 6.4 |
| assay format | 3 | 2 | 7.3 |
| tissue-based format | 2 | 22 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 52 | 6.3 |
| single protein format | 2 | 30 | 6.2 |