Assay Detail
Functional
CHEMBL1048181
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Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced TNFalpha production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.65 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462150 | — | — | 1 | 9.90 |
| CHEMBL570015 | GSK-256066 | 2.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462150 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL570015 | GSK-256066 | IC50 | = | 39.81 | nM | 7.40 |