Assay Detail
Functional
CHEMBL1048346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of agonist-induced calcium flux by fluorometric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.75 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255787 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255787 | — | IC50 | = | 18.0 | nM | 7.75 |