Assay Detail
Binding
CHEMBL1048412
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Noncompetitive type inhibition of human autotaxin at free state isolated from MDA-MB-231 cells assessed as blockade of FS3 substrate hydrolysis by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optimization of a pipemidic acid autotaxin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.19 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117021 | LYSOPHOSPHATIDIC ACID | — | 1 | 7.00 |
| CHEMBL570352 | — | — | 1 | 6.70 |
| CHEMBL570823 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117021 | LYSOPHOSPHATIDIC ACID | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL570352 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL570823 | — | Ki | = | 13200.0 | nM | 4.88 |