Assay Detail
ADMET
CHEMBL1048428
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Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 4.71 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.92 |
| CHEMBL568268 | — | — | 1 | 5.26 |
| CHEMBL583579 | — | — | 1 | 5.21 |
| CHEMBL565456 | — | — | 1 | 5.17 |
| CHEMBL570583 | — | — | 1 | 5.10 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 5.10 |
| CHEMBL575019 | — | — | 1 | 5.09 |
| CHEMBL570817 | — | — | 1 | 5.05 |
| CHEMBL575017 | — | — | 1 | 5.00 |
| CHEMBL575018 | — | — | 1 | 4.96 |
| CHEMBL578555 | — | — | 1 | 4.89 |
| CHEMBL565506 | — | — | 1 | 4.85 |
| CHEMBL571035 | — | — | 1 | 4.82 |
| CHEMBL568047 | — | — | 1 | 4.80 |
| CHEMBL568726 | — | — | 1 | 4.75 |
| CHEMBL575020 | — | — | 1 | 4.75 |
| CHEMBL571034 | — | — | 1 | 4.68 |
| CHEMBL576463 | — | — | 1 | 4.66 |
| CHEMBL566743 | — | — | 1 | 4.62 |
| CHEMBL566744 | — | — | 1 | 4.62 |
| CHEMBL566963 | — | — | 1 | 4.60 |
| CHEMBL570816 | — | — | 1 | 4.57 |
| CHEMBL569179 | — | — | 1 | 4.55 |
| CHEMBL577468 | — | — | 1 | 4.55 |
| CHEMBL568969 | — | — | 1 | 4.54 |
| CHEMBL570825 | — | — | 1 | 4.54 |
| CHEMBL569417 | — | — | 1 | 4.54 |
| CHEMBL576699 | — | — | 1 | 4.54 |
| CHEMBL569180 | — | — | 1 | 4.54 |
| CHEMBL569418 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL568268 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL583579 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL565456 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL570583 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL575019 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL570817 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL575017 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL575018 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL578555 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL565506 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL571035 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL568047 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL575020 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL568726 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL571034 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL576463 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL566743 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL566744 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL566963 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL570816 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL569179 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL577468 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL569180 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL570825 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL576699 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL568969 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL569417 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL569418 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL577334 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL565673 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL565455 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL577328 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL571251 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL575230 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL585745 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL585929 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL577467 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL578831 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL565505 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL579228 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL571472 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL571471 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL579024 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL571256 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL571051 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL583463 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL565672 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL569890 | — | IC50 | > | 180000.0 | nM | - |