Assay Detail
Functional
CHEMBL1048546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 with protease A71V, I84V L90M mutant by cell free assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.74 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583370 | — | — | 1 | 8.15 |
| CHEMBL583371 | — | — | 1 | 7.72 |
| CHEMBL574795 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583370 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL583371 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL574795 | — | EC50 | = | 44.0 | nM | 7.36 |