Assay Detail
Functional
CHEMBL1048603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at LXRbeta in mouse J774 cells assessed as upregulation of ABCA1 mRNA expression
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.15 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595124 | — | — | 1 | 7.92 |
| CHEMBL62136 | T091317 | — | 1 | 7.57 |
| CHEMBL606157 | — | — | 1 | 7.43 |
| CHEMBL214719 | — | — | 1 | 7.39 |
| CHEMBL604479 | — | — | 1 | 6.96 |
| CHEMBL593960 | — | — | 1 | 6.85 |
| CHEMBL596262 | — | — | 1 | 6.78 |
| CHEMBL595118 | — | — | 1 | 6.26 |
| CHEMBL603743 | — | — | 1 | - |
| CHEMBL595125 | — | — | 1 | - |
| CHEMBL596047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595124 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL62136 | T091317 | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL606157 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL214719 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL604479 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL593960 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL596262 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL595118 | — | EC50 | = | 555.0 | nM | 6.26 |
| CHEMBL603743 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL595125 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL596047 | — | EC50 | > | 1000.0 | nM | - |