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Assay Detail

CHEMBL1048736

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Molt4/C8 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MOLT-4
Confidence 1 — Organism
Curated By Autocuration

Publication

Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents.
Youssef D, Potter E, Jha M, De Clercq E, Balzarini J, Stables JP, Jha A.
Bioorg Med Chem Lett (2009) 19 : 6364 -6367
PubMed 19819135 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.25 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL158037 1 6.82
CHEMBL570628 1 6.68
CHEMBL577324 1 6.66
CHEMBL571870 1 6.64
CHEMBL577323 1 6.62
CHEMBL577326 1 6.62
CHEMBL577325 1 6.60
CHEMBL577533 1 6.57
CHEMBL577322 1 6.55
CHEMBL577109 1 6.24
CHEMBL570299 1 5.96
CHEMBL156016 1 5.85
CHEMBL585540 1 5.85
CHEMBL154716 1 5.78
CHEMBL852 MELPHALAN 4.0 1 5.49
CHEMBL348877 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL158037 IC50 = 150.0 nM 6.82
CHEMBL570628 IC50 = 210.0 nM 6.68
CHEMBL577324 IC50 = 220.0 nM 6.66
CHEMBL571870 IC50 = 230.0 nM 6.64
CHEMBL577323 IC50 = 240.0 nM 6.62
CHEMBL577326 IC50 = 240.0 nM 6.62
CHEMBL577325 IC50 = 250.0 nM 6.60
CHEMBL577533 IC50 = 270.0 nM 6.57
CHEMBL577322 IC50 = 280.0 nM 6.55
CHEMBL577109 IC50 = 570.0 nM 6.24
CHEMBL570299 IC50 = 1100.0 nM 5.96
CHEMBL156016 IC50 = 1420.0 nM 5.85
CHEMBL585540 IC50 = 1400.0 nM 5.85
CHEMBL154716 IC50 = 1670.0 nM 5.78
CHEMBL852 MELPHALAN IC50 = 3240.0 nM 5.49
CHEMBL348877 IC50 = 8280.0 nM 5.08