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Assay Detail

CHEMBL1048754

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Binding
Inhibition of HCV recombinant NS5B Cdelta21 RdRp expressed in Escherichia coli assessed as [3H]GTP incorporation after 3 hrs by scintillation proximity assay-based RNA polymerase assay
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.
Popovici-Muller J, Shipps GW, Rosner KE, Deng Y, Wang T, Curran PJ, Brown MA, Siddiqui MA, Cooper AB, Duca J, Cable M, Girijavallabhan V.
Bioorg Med Chem Lett (2009) 19 : 6331 -6336
PubMed 19819138 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 6.12 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL583349 — — 1 7.96
CHEMBL567918 — — 1 7.70
CHEMBL567926 — — 1 7.70
CHEMBL585316 — — 1 7.62
CHEMBL570969 — — 1 7.38
CHEMBL570629 — — 1 7.05
CHEMBL572287 — — 1 6.72
CHEMBL585687 — — 1 6.70
CHEMBL583480 — — 1 6.66
CHEMBL567906 — — 1 6.54
CHEMBL571421 — — 1 6.40
CHEMBL570983 — — 1 6.40
CHEMBL582819 — — 1 6.40
CHEMBL571021 — — 1 6.40
CHEMBL583459 — — 1 6.35
CHEMBL567305 — — 1 6.35
CHEMBL585102 — — 1 6.32
CHEMBL379677 — — 1 6.28
CHEMBL571637 — — 1 6.23
CHEMBL584333 — — 1 6.22
CHEMBL568931 — — 1 6.17
CHEMBL565640 — — 1 6.16
CHEMBL572049 — — 1 6.15
CHEMBL576101 — — 1 6.12
CHEMBL567098 — — 1 6.03
CHEMBL567697 — — 1 6.03
CHEMBL567927 — — 1 6.02
CHEMBL175177 — — 1 5.80
CHEMBL572262 — — 1 5.80
CHEMBL570786 — — 1 5.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL583349 — IC50 = 11.0 nM 7.96
CHEMBL567918 — IC50 = 20.0 nM 7.70
CHEMBL567926 — IC50 = 20.0 nM 7.70
CHEMBL585316 — IC50 = 24.0 nM 7.62
CHEMBL570969 — IC50 = 42.0 nM 7.38
CHEMBL570629 — IC50 = 90.0 nM 7.05
CHEMBL572287 — IC50 = 190.0 nM 6.72
CHEMBL585687 — IC50 = 200.0 nM 6.70
CHEMBL583480 — IC50 = 220.0 nM 6.66
CHEMBL567906 — IC50 = 290.0 nM 6.54
CHEMBL571021 — IC50 = 400.0 nM 6.40
CHEMBL582819 — IC50 = 400.0 nM 6.40
CHEMBL570983 — IC50 = 400.0 nM 6.40
CHEMBL571421 — IC50 = 400.0 nM 6.40
CHEMBL567305 — IC50 = 450.0 nM 6.35
CHEMBL583459 — IC50 = 450.0 nM 6.35
CHEMBL585102 — IC50 = 480.0 nM 6.32
CHEMBL379677 — IC50 = 530.0 nM 6.28
CHEMBL571637 — IC50 = 590.0 nM 6.23
CHEMBL584333 — IC50 = 600.0 nM 6.22
CHEMBL568931 — IC50 = 670.0 nM 6.17
CHEMBL565640 — IC50 = 700.0 nM 6.16
CHEMBL572049 — IC50 = 710.0 nM 6.15
CHEMBL576101 — IC50 = 760.0 nM 6.12
CHEMBL567697 — IC50 = 930.0 nM 6.03
CHEMBL567098 — IC50 = 930.0 nM 6.03
CHEMBL567927 — IC50 = 960.0 nM 6.02
CHEMBL175177 — IC50 = 1600.0 nM 5.80
CHEMBL572262 — IC50 = 1600.0 nM 5.80
CHEMBL570786 — IC50 = 1900.0 nM 5.72
CHEMBL567726 — IC50 = 2000.0 nM 5.70
CHEMBL566027 — IC50 = 2800.0 nM 5.55
CHEMBL572078 — IC50 = 3400.0 nM 5.47
CHEMBL585728 — IC50 = 4600.0 nM 5.34
CHEMBL585156 — IC50 = 5700.0 nM 5.24
CHEMBL570785 — IC50 = 6000.0 nM 5.22
CHEMBL583350 — IC50 = 6000.0 nM 5.22
CHEMBL583250 — IC50 = 8600.0 nM 5.07
CHEMBL583907 — IC50 = 12000.0 nM 4.92
CHEMBL579020 — IC50 = 12500.0 nM 4.90
CHEMBL570530 — IC50 = 12500.0 nM 4.90
CHEMBL568930 — IC50 = 50000.0 nM 4.30
CHEMBL584119 — IC50 - — -
CHEMBL571014 — IC50 - — -
CHEMBL583037 — IC50 - — -
CHEMBL572291 — IC50 - — -