Assay Detail
Functional
CHEMBL1049519
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Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 4.52 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589866 | — | — | 1 | 5.03 |
| CHEMBL590847 | — | — | 1 | 4.94 |
| CHEMBL589870 | — | — | 1 | 4.84 |
| CHEMBL590846 | — | — | 1 | 4.80 |
| CHEMBL589871 | — | — | 1 | 4.56 |
| CHEMBL594133 | — | — | 1 | 4.34 |
| CHEMBL293492 | CINNAMALDEHYDE | -1.0 | 1 | 4.29 |
| CHEMBL589875 | — | — | 1 | 4.20 |
| CHEMBL589873 | — | — | 1 | 4.16 |
| CHEMBL589794 | — | — | 1 | 4.01 |
| CHEMBL602101 | — | — | 1 | - |
| CHEMBL590119 | — | — | 1 | - |
| CHEMBL590118 | — | — | 1 | - |
| CHEMBL603735 | — | — | 1 | - |
| CHEMBL593903 | — | — | 1 | - |
| CHEMBL590845 | — | — | 1 | - |
| CHEMBL594134 | — | — | 1 | - |
| CHEMBL589872 | — | — | 1 | - |
| CHEMBL589874 | — | — | 1 | - |
| CHEMBL593902 | AP18 5 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589866 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL590847 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL589870 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL590846 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL589871 | — | EC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL594133 | — | EC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL293492 | CINNAMALDEHYDE | EC50 | = | 51400.0 | nM | 4.29 |
| CHEMBL589875 | — | EC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL589873 | — | EC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL589794 | — | EC50 | = | 96600.0 | nM | 4.01 |
| CHEMBL602101 | — | EC50 | - | — | - | |
| CHEMBL590119 | — | EC50 | - | — | - | |
| CHEMBL590118 | — | EC50 | - | — | - | |
| CHEMBL603735 | — | EC50 | - | — | - | |
| CHEMBL593903 | — | EC50 | - | — | - | |
| CHEMBL590845 | — | EC50 | - | — | - | |
| CHEMBL594134 | — | EC50 | - | — | - | |
| CHEMBL589872 | — | EC50 | - | — | - | |
| CHEMBL589874 | — | EC50 | - | — | - | |
| CHEMBL593902 | AP18 5 | EC50 | - | — | - |