Assay Detail
Binding
CHEMBL1049703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Schneider 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proprotein convertase subtilisin/kexin type 7 (CHEMBL2232) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.50 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568525 | — | — | 1 | 6.01 |
| CHEMBL569918 | — | — | 1 | 5.29 |
| CHEMBL566340 | — | — | 1 | 5.21 |
| CHEMBL569280 | — | — | 1 | - |
| CHEMBL568067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568525 | — | Ki | = | 968.0 | nM | 6.01 |
| CHEMBL569918 | — | Ki | = | 5131.0 | nM | 5.29 |
| CHEMBL566340 | — | Ki | = | 6154.0 | nM | 5.21 |
| CHEMBL569280 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL568067 | — | Ki | > | 10000.0 | nM | - |