Proprotein convertase subtilisin/kexin type 7 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q16549. Use UniProt Q16549 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16549 as the stable identity anchor, then attach disease evidence before program review.
Proprotein convertase subtilisin/kexin type 7
Review this target as Proprotein convertase subtilisin/kexin type 7, mapped to UniProt Q16549. Sequence length is 785 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Proprotein convertase subtilisin/kexin type 7 as ChEMBL target CHEMBL2232, mapped to UniProt Q16549. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Proprotein convertase subtilisin/kexin type 7 is the right protein anchor across sources, using UniProt Q16549 as the stable mapping.
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| Preferred Name | Proprotein convertase subtilisin/kexin type 7 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16549 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Proprotein convertase subtilisin/kexin type 7 |
| UniProt Accession | Q16549 |
| Component Type | Protein |
| Sequence Length | 785 aa |
Proprotein convertase subtilisin/kexin type 7
Review this target as Proprotein convertase subtilisin/kexin type 7, mapped to UniProt Q16549. Sequence length is 785 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3126388 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL3115771 | 7.86 | Ki | 13.8 | Preclinical |
| CHEMBL3115770 | 7.14 | Ki | 72.0 | Preclinical |
| CHEMBL502642 | 6.87 | Ki | 135.0 | Preclinical |
| CHEMBL525748 | 6.87 | Ki | 135.0 | Preclinical |
| CHEMBL503520 | 6.76 | Ki | 172.0 | Preclinical |
| CHEMBL455792 | 6.69 | Ki | 206.0 | Preclinical |
| CHEMBL1813183 | 6.33 | IC50 | 462.0 | Preclinical |
| CHEMBL568525 | 6.01 | Ki | 968.0 | Preclinical |
| CHEMBL500184 | 5.95 | Ki | 1133.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 9 | 6.2 |
| cell-based format | 3 | 6 | 6.9 |