Compound Detail
CHEMBL525748
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CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL525748 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | ALKYWGCWYLWWQX-WEOSOBNISA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1436.8
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Furin CHEMBL2611 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Proprotein convertase subtilisin/kexin type 7 CHEMBL2232 | Ki | 6.87 | 6.87 | 135.0 | 1 |
| Proprotein convertase subtilisin/kexin type 6 CHEMBL5507 | Ki | 6.57 | 6.57 | 267.0 | 1 |
| Proprotein convertase subtilisin/kexin type 5 CHEMBL2826 | Ki | 6.31 | 6.31 | 492.0 | 1 |
| Proprotein convertase subtilisin/kexin type 4 CHEMBL4861 | Ki | 6.25 | 6.25 | 562.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17537721 | 10.1074/jbc.m703847200 | Furin | 1 |
| 17537721 | 10.1074/jbc.m703847200 | Proprotein convertase subtilisin/kexin type 6 | 1 |
| 17537721 | 10.1074/jbc.m703847200 | Proprotein convertase subtilisin/kexin type 4 | 1 |
| 17537721 | 10.1074/jbc.m703847200 | Proprotein convertase subtilisin/kexin type 5 | 1 |
| 17537721 | 10.1074/jbc.m703847200 | Proprotein convertase subtilisin/kexin type 7 | 1 |
Data from ChEMBL 36 via Core Engine