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Assay Detail

CHEMBL1050397

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei brucei after 48 hrs by luminescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis.
Hwang JY, Smithson D, Connelly M, Maier J, Zhu F, Guy KR.
Bioorg Med Chem Lett (2010) 20 : 149 -152
PubMed 19963377 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.97 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL592497 1 6.00
CHEMBL603826 1 5.82
CHEMBL591552 1 5.82
CHEMBL591315 1 5.22
CHEMBL602996 1 5.11
CHEMBL602546 1 4.92
CHEMBL585955 1 4.72
CHEMBL591551 1 4.72
CHEMBL592499 1 4.68
CHEMBL592253 1 4.65
CHEMBL585463 1 4.62
CHEMBL592736 1 4.62
CHEMBL589129 1 4.61
CHEMBL591784 1 4.57
CHEMBL602995 1 4.53
CHEMBL591314 1 -
CHEMBL601093 1 -
CHEMBL591312 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL592497 IC50 = 1000.0 nM 6.00
CHEMBL603826 IC50 = 1500.0 nM 5.82
CHEMBL591552 IC50 = 1500.0 nM 5.82
CHEMBL591315 IC50 = 6000.0 nM 5.22
CHEMBL602996 IC50 = 7700.0 nM 5.11
CHEMBL602546 IC50 = 11900.0 nM 4.92
CHEMBL585955 IC50 = 19000.0 nM 4.72
CHEMBL591551 IC50 = 19200.0 nM 4.72
CHEMBL592499 IC50 = 20800.0 nM 4.68
CHEMBL592253 IC50 = 22500.0 nM 4.65
CHEMBL585463 IC50 = 24000.0 nM 4.62
CHEMBL592736 IC50 = 24000.0 nM 4.62
CHEMBL589129 IC50 = 24500.0 nM 4.61
CHEMBL591784 IC50 = 27000.0 nM 4.57
CHEMBL602995 IC50 = 29800.0 nM 4.53
CHEMBL591314 IC50 > 50000.0 nM -
CHEMBL601093 IC50 > 50000.0 nM -
CHEMBL591312 IC50 > 50000.0 nM -