Assay Detail
Binding
CHEMBL1050612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Src
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.07 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576218 | — | — | 1 | 8.04 |
| CHEMBL566635 | — | — | 1 | 7.75 |
| CHEMBL585666 | — | — | 1 | 7.52 |
| CHEMBL565366 | — | — | 1 | 7.46 |
| CHEMBL566636 | — | — | 1 | 7.44 |
| CHEMBL567068 | — | — | 1 | 7.42 |
| CHEMBL577269 | — | — | 1 | 7.42 |
| CHEMBL566850 | — | — | 1 | 7.37 |
| CHEMBL327127 | — | — | 1 | 7.37 |
| CHEMBL321193 | — | — | 1 | 7.37 |
| CHEMBL566834 | — | — | 1 | 7.18 |
| CHEMBL565801 | — | — | 1 | 6.82 |
| CHEMBL565609 | — | — | 1 | 6.67 |
| CHEMBL323405 | — | — | 1 | 6.65 |
| CHEMBL565372 | — | — | 1 | 6.63 |
| CHEMBL570175 | — | — | 1 | 6.47 |
| CHEMBL565587 | — | — | 1 | 6.36 |
| CHEMBL111339 | — | — | 1 | 6.31 |
| CHEMBL574059 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576218 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL566635 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL585666 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL565366 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL566636 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL567068 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL577269 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL566850 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL327127 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL321193 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL566834 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL565801 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL565609 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL323405 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL565372 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL570175 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL565587 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL111339 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL574059 | — | IC50 | = | 921.0 | nM | 6.04 |