Compound Detail
CHEMBL565609
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Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(NC(=O)CCNC(=O)OC(C)(C)C)cc3)nc21
Basic Information
| ChEMBL ID | CHEMBL565609 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APGJWCRRERWKDQ-UHFFFAOYSA-N |
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
583.5
MW (Da)
5.90
ALogP
8
HBA
3
HBD
127.2
PSA (Ų)
0.25
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase ABL1 CHEMBL1862 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| K562 CHEMBL385 | IC50 | 7.05 | 7.05 | 90.0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 6.67 | 6.67 | 213.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 6.52 | 6.52 | 299.0 | 1 |
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 6.51 | 6.51 | 311.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.38 | 6.38 | 415.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase ABL1 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of human recombinant Abl | 19889540 |
| K562 | IC50 | = | 90.0 | nM | 7.05 | Cytotoxicity against Philadelphia chromosome positive human K562 cells by Alamar... | 19889540 |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 213.0 | nM | 6.67 | Inhibition of human recombinant Src | 19889540 |
| Mitogen-activated protein kinase 14 | IC50 | = | 299.0 | nM | 6.52 | Inhibition of human recombinant P38alpha | 19889540 |
| Platelet-derived growth factor receptor | IC50 | = | 311.0 | nM | 6.51 | Inhibition of human recombinant PDGFR | 19889540 |
| Unchecked | IC50 | = | 415.0 | nM | 6.38 | Inhibition of human recombinant VEGFR | 19889540 |
| NON-PROTEIN TARGET | IC50 | = | 2800.0 | nM | 5.55 | Cytotoxicity against Philadelphia chromosome positive human ALL3 cells by Alamar... | 19889540 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Unchecked | 5 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | NON-PROTEIN TARGET | 4 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | MEG-01 | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | K562 | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Mast/stem cell growth factor receptor Kit | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Platelet-derived growth factor receptor | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Mitogen-activated protein kinase 14 | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Tyrosine-protein kinase ABL1 | 1 |
| 19889540 | 10.1016/j.bmcl.2009.10.085 | Jurkat | 1 |
Data from ChEMBL 36 via Core Engine