Assay Detail
Binding
CHEMBL1050608
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Inhibition of human recombinant Abl
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.25 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585666 | — | — | 1 | 8.85 |
| CHEMBL567068 | — | — | 1 | 8.64 |
| CHEMBL566636 | — | — | 1 | 8.64 |
| CHEMBL577269 | — | — | 1 | 8.60 |
| CHEMBL321193 | — | — | 1 | 8.59 |
| CHEMBL327127 | — | — | 1 | 8.55 |
| CHEMBL565366 | — | — | 1 | 8.44 |
| CHEMBL566635 | — | — | 1 | 8.33 |
| CHEMBL566850 | — | — | 1 | 8.32 |
| CHEMBL566834 | — | — | 1 | 8.31 |
| CHEMBL565801 | — | — | 1 | 8.30 |
| CHEMBL323405 | — | — | 1 | 8.28 |
| CHEMBL565587 | — | — | 1 | 8.12 |
| CHEMBL576218 | — | — | 1 | 8.09 |
| CHEMBL565609 | — | — | 1 | 7.92 |
| CHEMBL570175 | — | — | 1 | 7.89 |
| CHEMBL574059 | — | — | 1 | 7.68 |
| CHEMBL565372 | — | — | 1 | 7.66 |
| CHEMBL111339 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585666 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL567068 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL566636 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL577269 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL321193 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL327127 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL565366 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL566635 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL566850 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL566834 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL565801 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL323405 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL565587 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL576218 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL565609 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL570175 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL574059 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL565372 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL111339 | — | IC50 | = | 30.0 | nM | 7.52 |