Assay Detail
Binding
CHEMBL1050609
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Inhibition of human recombinant P38alpha
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.96 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565366 | — | — | 1 | 8.00 |
| CHEMBL585666 | — | — | 1 | 7.82 |
| CHEMBL567068 | — | — | 1 | 7.50 |
| CHEMBL566635 | — | — | 1 | 7.47 |
| CHEMBL574059 | — | — | 1 | 7.30 |
| CHEMBL566636 | — | — | 1 | 7.29 |
| CHEMBL323405 | — | — | 1 | 6.98 |
| CHEMBL566850 | — | — | 1 | 6.97 |
| CHEMBL576218 | — | — | 1 | 6.96 |
| CHEMBL577269 | — | — | 1 | 6.88 |
| CHEMBL565587 | — | — | 1 | 6.87 |
| CHEMBL327127 | — | — | 1 | 6.85 |
| CHEMBL321193 | — | — | 1 | 6.73 |
| CHEMBL570175 | — | — | 1 | 6.65 |
| CHEMBL565801 | — | — | 1 | 6.60 |
| CHEMBL565609 | — | — | 1 | 6.52 |
| CHEMBL566834 | — | — | 1 | 6.48 |
| CHEMBL111339 | — | — | 1 | 6.31 |
| CHEMBL565372 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565366 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL585666 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL567068 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL566635 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL574059 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL566636 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL323405 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL566850 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL576218 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL577269 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL565587 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL327127 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL321193 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL570175 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL565801 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL565609 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL566834 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL111339 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL565372 | — | IC50 | = | 752.0 | nM | 6.12 |