Assay Detail
Binding
CHEMBL1050896
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Inhibition of PTPN2
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.43 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243942 | — | — | 1 | 7.44 |
| CHEMBL215335 | — | — | 1 | 6.85 |
| CHEMBL139393 | — | — | 1 | 6.54 |
| CHEMBL577144 | — | — | 1 | 6.22 |
| CHEMBL214378 | — | — | 1 | 6.09 |
| CHEMBL379196 | — | — | 1 | 5.80 |
| CHEMBL213758 | — | — | 1 | 5.50 |
| CHEMBL341806 | — | — | 1 | 5.10 |
| CHEMBL138152 | — | — | 1 | 5.09 |
| CHEMBL583175 | — | — | 1 | 5.04 |
| CHEMBL573989 | — | — | 1 | 5.00 |
| CHEMBL342478 | — | — | 1 | 4.85 |
| CHEMBL336908 | — | — | 1 | 4.85 |
| CHEMBL138806 | — | — | 1 | 4.85 |
| CHEMBL139050 | — | — | 1 | 4.64 |
| CHEMBL336879 | — | — | 1 | 4.24 |
| CHEMBL342612 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243942 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL215335 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL139393 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL577144 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL214378 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL379196 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL213758 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL341806 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL138152 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL583175 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL573989 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL342478 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL336908 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL138806 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL139050 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL336879 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL342612 | — | Ki | = | 62000.0 | nM | 4.21 |