Assay Detail
Binding
CHEMBL1051620
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Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.03 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552717 | — | — | 1 | 5.28 |
| CHEMBL538895 | — | — | 1 | 5.14 |
| CHEMBL554122 | ICTEROGENIN | — | 1 | 5.12 |
| CHEMBL557340 | — | — | 1 | 4.85 |
| CHEMBL539907 | — | — | 1 | 4.75 |
| CHEMBL558462 | — | — | 1 | - |
| CHEMBL552716 | — | — | 1 | - |
| CHEMBL538412 | — | — | 1 | - |
| CHEMBL542004 | — | — | 1 | - |
| CHEMBL539908 | — | — | 1 | - |
| CHEMBL553855 | — | — | 1 | - |
| CHEMBL560651 | — | — | 1 | - |
| CHEMBL510691 | LANTADENE A | — | 1 | - |
| CHEMBL555367 | LANTADENE B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552717 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL538895 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL554122 | ICTEROGENIN | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL557340 | — | Ki | = | 14100.0 | nM | 4.85 |
| CHEMBL539907 | — | Ki | = | 17800.0 | nM | 4.75 |
| CHEMBL558462 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL552716 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL538412 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL542004 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL539908 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL553855 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL560651 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL510691 | LANTADENE A | Ki | > | 100000.0 | nM | - |
| CHEMBL555367 | LANTADENE B | Ki | > | 100000.0 | nM | - |