Assay Detail
Binding
CHEMBL1051709
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Inhibition of Cav 1.2 channel
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL1940) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.04 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561788 | — | — | 1 | 5.70 |
| CHEMBL552061 | — | — | 1 | 5.52 |
| CHEMBL551921 | — | — | 1 | 5.17 |
| CHEMBL562869 | — | — | 1 | 4.96 |
| CHEMBL552402 | — | — | 1 | 4.92 |
| CHEMBL555347 | — | — | 1 | 4.82 |
| CHEMBL564757 | — | — | 1 | 4.72 |
| CHEMBL562926 | — | — | 1 | 4.52 |
| CHEMBL550652 | — | — | 1 | - |
| CHEMBL563732 | — | — | 1 | - |
| CHEMBL559101 | — | — | 1 | - |
| CHEMBL552196 | — | — | 1 | - |
| CHEMBL561379 | — | — | 1 | - |
| CHEMBL561259 | — | — | 1 | - |
| CHEMBL564547 | — | — | 1 | - |
| CHEMBL551058 | — | — | 1 | - |
| CHEMBL559531 | — | — | 1 | - |
| CHEMBL552382 | — | — | 2 | - |
| CHEMBL556487 | — | — | 1 | - |
| CHEMBL557032 | — | — | 1 | - |
| CHEMBL551517 | — | — | 1 | - |
| CHEMBL550242 | — | — | 1 | - |
| CHEMBL564975 | — | — | 1 | - |
| CHEMBL562822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561788 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL552061 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL551921 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL562869 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL552402 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL555347 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL564757 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL562926 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL550652 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL563732 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL559101 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL552196 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL561379 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL561259 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL564547 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL551058 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL559531 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL552382 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL556487 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL557032 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL551517 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL550242 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL562822 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL564975 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL552382 | — | IC50 | > | 30000.0 | nM | - |