Assay Detail
Binding
CHEMBL1051756
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Inhibition of PTP1B by pNPP hydrolase assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.74 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184041 | ERTIPROTAFIB | 2.0 | 1 | 5.85 |
| CHEMBL557446 | — | — | 1 | 4.96 |
| CHEMBL564123 | — | — | 1 | 4.92 |
| CHEMBL559479 | — | — | 1 | 4.66 |
| CHEMBL556909 | — | — | 1 | 4.60 |
| CHEMBL552066 | — | — | 1 | 4.57 |
| CHEMBL564092 | — | — | 1 | 4.55 |
| CHEMBL549640 | — | — | 1 | 4.47 |
| CHEMBL565229 | — | — | 1 | 4.46 |
| CHEMBL549911 | — | — | 1 | 4.39 |
| CHEMBL139393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184041 | ERTIPROTAFIB | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL557446 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL564123 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL559479 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL556909 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL552066 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL564092 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL549640 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL565229 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL549911 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL139393 | — | IC50 | = | 500000.0 | nM | - |