Assay Detail
Binding
CHEMBL1052124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bFGFR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.45 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327127 | — | — | 1 | 7.21 |
| CHEMBL106772 | — | — | 1 | 7.00 |
| CHEMBL573820 | — | — | 1 | 6.61 |
| CHEMBL578006 | — | — | 1 | 6.35 |
| CHEMBL574059 | — | — | 1 | 6.03 |
| CHEMBL574058 | — | — | 1 | 6.03 |
| CHEMBL386051 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327127 | — | IC50 | = | 61.5 | nM | 7.21 |
| CHEMBL106772 | — | IC50 | = | 98.8 | nM | 7.00 |
| CHEMBL573820 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL578006 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL574059 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL574058 | — | IC50 | = | 934.0 | nM | 6.03 |
| CHEMBL386051 | — | IC50 | = | 1250.0 | nM | 5.90 |