Assay Detail
Functional
CHEMBL1052128
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Inhibition of 3H-thymidine incorporation into A-431 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.54 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574058 | — | — | 1 | 6.67 |
| CHEMBL106772 | — | — | 1 | 6.61 |
| CHEMBL578006 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574058 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL106772 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL578006 | — | IC50 | = | 445.0 | nM | 6.35 |