Assay Detail
Binding
CHEMBL1052236
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Displacement of [3H]NECA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.15 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576395 | — | — | 1 | 6.96 |
| CHEMBL568307 | — | — | 1 | 6.29 |
| CHEMBL567412 | — | — | 1 | 6.08 |
| CHEMBL583862 | — | — | 1 | 5.80 |
| CHEMBL582921 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576395 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL568307 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL567412 | — | Ki | = | 839.0 | nM | 6.08 |
| CHEMBL583862 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL582921 | — | Ki | = | 2320.0 | nM | 5.63 |