Assay Detail
Binding
CHEMBL1052237
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Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.08 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573937 | — | — | 1 | 7.74 |
| CHEMBL567226 | — | — | 1 | 6.58 |
| CHEMBL583132 | — | — | 1 | 6.34 |
| CHEMBL565678 | — | — | 1 | 6.32 |
| CHEMBL583637 | — | — | 1 | 6.16 |
| CHEMBL490606 | — | — | 1 | 5.75 |
| CHEMBL490605 | — | — | 1 | 5.52 |
| CHEMBL523797 | — | — | 1 | 5.51 |
| CHEMBL257833 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573937 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL567226 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL583132 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL565678 | — | Ki | = | 482.0 | nM | 6.32 |
| CHEMBL583637 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL490606 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL490605 | — | Ki | = | 3040.0 | nM | 5.52 |
| CHEMBL523797 | — | Ki | = | 3070.0 | nM | 5.51 |
| CHEMBL257833 | — | Ki | = | 14900.0 | nM | 4.83 |