Assay Detail
Functional
CHEMBL1052829
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Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.60 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565714 | — | — | 1 | 7.15 |
| CHEMBL583218 | — | — | 1 | 7.05 |
| CHEMBL567197 | — | — | 1 | 6.89 |
| CHEMBL578044 | — | — | 1 | 6.89 |
| CHEMBL583403 | — | — | 1 | 6.72 |
| CHEMBL565467 | — | — | 1 | 6.54 |
| CHEMBL566350 | — | — | 1 | 6.51 |
| CHEMBL584714 | — | — | 1 | 6.51 |
| CHEMBL1645462 | AC-480 | 1.0 | 1 | 6.51 |
| CHEMBL567873 | — | — | 1 | 6.38 |
| CHEMBL566559 | — | — | 1 | 6.33 |
| CHEMBL578255 | — | — | 1 | 6.26 |
| CHEMBL566337 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565714 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL583218 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL567197 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL578044 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL583403 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL565467 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL566350 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL584714 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1645462 | AC-480 | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL567873 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL566559 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL578255 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL566337 | — | IC50 | = | 860.0 | nM | 6.07 |