Assay Detail
Binding
CHEMBL1052925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Clonidine from alpha2 adrenergic receptor in Wistar rat cerebral cortex membrane by liquid scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.43 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477465 | — | — | 1 | 8.85 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 8.47 |
| CHEMBL572571 | — | — | 1 | 7.37 |
| CHEMBL573946 | — | — | 1 | 7.25 |
| CHEMBL573951 | — | — | 1 | 7.21 |
| CHEMBL582863 | — | — | 1 | 6.96 |
| CHEMBL574593 | — | — | 1 | 6.74 |
| CHEMBL573945 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477465 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL723 | CARVEDILOL | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL572571 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL573946 | — | Ki | = | 56.9 | nM | 7.25 |
| CHEMBL573951 | — | Ki | = | 60.9 | nM | 7.21 |
| CHEMBL582863 | — | Ki | = | 108.8 | nM | 6.96 |
| CHEMBL574593 | — | Ki | = | 180.8 | nM | 6.74 |
| CHEMBL573945 | — | Ki | = | 277.2 | nM | 6.56 |