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Assay Detail

CHEMBL1052987

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against diamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243-As10-3 after 48 hrs by Z1 zoulter counter
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
Sufrin JR, Spiess AJ, Marasco CJ, Rattendi D, Bacchi CJ.
Antimicrob Agents Chemother (2008) 52 : 211 -219
PubMed 17954686 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 5.58 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL559577 1 8.00
CHEMBL563075 1 6.82
CHEMBL380728 1 6.58
CHEMBL552247 1 6.55
CHEMBL191917 1 6.35
CHEMBL559971 1 6.22
CHEMBL552514 1 6.18
CHEMBL569592 1 5.92
CHEMBL563721 1 5.52
CHEMBL564336 1 5.26
CHEMBL571441 1 5.19
CHEMBL554744 1 5.17
CHEMBL565051 1 4.83
CHEMBL538693 1 4.80
CHEMBL551645 1 4.72
CHEMBL549763 1 4.69
CHEMBL555125 1 4.60
CHEMBL560447 1 4.39
CHEMBL554392 1 4.14
CHEMBL571674 1 -
CHEMBL550640 1 -
CHEMBL555063 1 -
CHEMBL551243 1 -
CHEMBL551375 1 -
CHEMBL564320 1 -
CHEMBL563153 1 -
CHEMBL551576 1 -
CHEMBL562742 1 -
CHEMBL560770 1 -
CHEMBL555425 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL559577 IC50 = 10.0 nM 8.00
CHEMBL563075 IC50 = 150.0 nM 6.82
CHEMBL380728 IC50 = 260.0 nM 6.58
CHEMBL552247 IC50 = 280.0 nM 6.55
CHEMBL191917 IC50 = 450.0 nM 6.35
CHEMBL559971 IC50 = 600.0 nM 6.22
CHEMBL552514 IC50 = 660.0 nM 6.18
CHEMBL569592 IC50 = 1200.0 nM 5.92
CHEMBL563721 IC50 = 3000.0 nM 5.52
CHEMBL564336 IC50 = 5500.0 nM 5.26
CHEMBL571441 IC50 = 6400.0 nM 5.19
CHEMBL554744 IC50 = 6700.0 nM 5.17
CHEMBL565051 IC50 = 14900.0 nM 4.83
CHEMBL538693 IC50 = 15750.0 nM 4.80
CHEMBL551645 IC50 = 19000.0 nM 4.72
CHEMBL549763 IC50 = 20500.0 nM 4.69
CHEMBL555125 IC50 = 25000.0 nM 4.60
CHEMBL560447 IC50 = 40500.0 nM 4.39
CHEMBL554392 IC50 = 72000.0 nM 4.14
CHEMBL558887 IC50 - -
CHEMBL551561 IC50 > 100000.0 nM -
CHEMBL559285 IC50 - -
CHEMBL559286 IC50 - -
CHEMBL277041 METHYLTHIOADENOSINE IC50 - -
CHEMBL195660 IC50 - -
CHEMBL551103 IC50 - -
CHEMBL551104 IC50 - -
CHEMBL552248 IC50 - -
CHEMBL551571 IC50 - -
CHEMBL563938 IC50 - -
CHEMBL557087 IC50 - -
CHEMBL562307 IC50 > 100000.0 nM -
CHEMBL560645 IC50 - -
CHEMBL555425 IC50 - -
CHEMBL560770 IC50 - -
CHEMBL562742 IC50 - -
CHEMBL551576 IC50 - -
CHEMBL563153 IC50 > 100000.0 nM -
CHEMBL564320 IC50 - -
CHEMBL551375 IC50 - -
CHEMBL551243 IC50 - -
CHEMBL555063 IC50 > 100000.0 nM -
CHEMBL550640 IC50 > 100000.0 nM -
CHEMBL571674 IC50 - -