Assay Detail
Binding
CHEMBL1053309
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Inhibition of recombinant GSK3-beta by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.01 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41016 | — | — | 1 | 5.38 |
| CHEMBL568905 | — | — | 1 | 5.19 |
| CHEMBL569595 | — | — | 1 | 5.16 |
| CHEMBL459575 | — | — | 1 | 5.11 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 4.91 |
| CHEMBL460627 | — | — | 1 | 4.87 |
| CHEMBL432684 | 4-HYDROXYPHENYLMETHYLENE HYDANTOIN | — | 1 | 4.86 |
| CHEMBL38043 | — | — | 1 | 4.85 |
| CHEMBL290184 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41016 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL568905 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL569595 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL459575 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL460627 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL432684 | 4-HYDROXYPHENYLMETHYLENE HYDANTOIN | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL38043 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL290184 | — | IC50 | = | 18200.0 | nM | 4.74 |