Compound Detail
CHEMBL432684
4-HYDROXYPHENYLMETHYLENE HYDANTOIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL432684 |
| Name | 4-HYDROXYPHENYLMETHYLENE HYDANTOIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UPDDIBZITPTASO-YVMONPNESA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
204.2
MW (Da)
0.57
ALogP
3
HBA
3
HBD
78.4
PSA (Ų)
0.46
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.86
EC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 4.86 | 4.86 | 13700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | IC50 | = | 13700.0 | nM | 4.86 | Inhibition of recombinant GSK3-beta by ELISA | 19616957 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19195897 | 10.1016/j.bmc.2008.12.053 | NON-PROTEIN TARGET | 3 |
| 20869139 | 10.1016/j.ejmech.2010.08.066 | PC-3 | 3 |
| 22077389 | 10.1021/jm201243p | Unchecked | 3 |
| 14998338 | 10.1021/jm030450c | Mus musculus | 2 |
| 19616957 | 10.1016/j.bmc.2009.06.054 | Glycogen synthase kinase-3 beta | 1 |
| 19904929 | 10.1021/jm901183d | RAW264.7 | 1 |
| 20420415 | 10.1021/np900787p | PC-3 | 1 |
| 21775154 | 10.1016/j.bmc.2011.06.060 | PC-3 | 1 |
| 21775154 | 10.1016/j.bmc.2011.06.060 | MDA-MB-231 | 1 |
| 22077389 | 10.1021/jm201243p | Prothrombin | 1 |
| - | 10.1007/s00044-013-0495-6 | PC-3 | 1 |
Data from ChEMBL 36 via Core Engine