Assay Detail
Binding
CHEMBL1053708
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Binding affinity to rat adenosine A3 receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.74 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583745 | — | — | 1 | 8.06 |
| CHEMBL574212 | — | — | 1 | 8.02 |
| CHEMBL583862 | — | — | 1 | 7.69 |
| CHEMBL257833 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583745 | — | Ki | = | 8.68 | nM | 8.06 |
| CHEMBL574212 | — | Ki | = | 9.62 | nM | 8.02 |
| CHEMBL583862 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL257833 | — | Ki | = | 66.5 | nM | 7.18 |