Assay Detail
Functional
CHEMBL1053922
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Cytotoxicity against human HCT116 cells after 3 days by MTT assay
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemistry of renieramycins. Part 8: synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.65 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557545 | CYANOJORUMYCIN | — | 1 | 8.49 |
| CHEMBL554575 | — | — | 1 | 8.48 |
| CHEMBL539919 | — | — | 1 | 8.10 |
| CHEMBL451147 | RENIERAMYCIN M | — | 2 | 8.03 |
| CHEMBL541946 | — | — | 1 | 8.00 |
| CHEMBL557490 | — | — | 1 | 8.00 |
| CHEMBL552534 | — | — | 1 | 8.00 |
| CHEMBL555509 | — | — | 1 | 7.96 |
| CHEMBL554604 | JORUNNAMYCIN C | — | 1 | 7.96 |
| CHEMBL556936 | — | — | 1 | 7.80 |
| CHEMBL558741 | — | — | 1 | 7.66 |
| CHEMBL552962 | — | — | 1 | 7.60 |
| CHEMBL556376 | — | — | 1 | 7.58 |
| CHEMBL539690 | — | — | 1 | 7.58 |
| CHEMBL541945 | — | — | 1 | 7.57 |
| CHEMBL540927 | — | — | 1 | 7.48 |
| CHEMBL554605 | — | — | 1 | 7.48 |
| CHEMBL554330 | — | — | 1 | 7.48 |
| CHEMBL554331 | — | — | 1 | 7.47 |
| CHEMBL539188 | — | — | 1 | 7.47 |
| CHEMBL541248 | — | — | 1 | 7.42 |
| CHEMBL559344 | — | — | 1 | 7.42 |
| CHEMBL562940 | — | — | 1 | 7.37 |
| CHEMBL541008 | — | — | 1 | 7.31 |
| CHEMBL555298 | — | — | 1 | 7.03 |
| CHEMBL555490 | — | — | 1 | 7.00 |
| CHEMBL549905 | JOURNNAMYCIN A | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557545 | CYANOJORUMYCIN | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL554575 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL539919 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL541946 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL557490 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL552534 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL555509 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL554604 | JORUNNAMYCIN C | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL556936 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL558741 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL552962 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL539690 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL556376 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL541945 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL540927 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL554605 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL554330 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL554331 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL539188 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL541248 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL559344 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL562940 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL541008 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL555298 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL555490 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL549905 | JOURNNAMYCIN A | IC50 | = | 130.0 | nM | 6.89 |