Assay Detail
Functional
CHEMBL1053981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity against methoxamine-induced contraction in spontaneously hypersensitive rat mesenteric artery assessed as reversal of methoxamine-induced vascular contraction
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Artery |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.01 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562822 | — | — | 1 | 5.19 |
| CHEMBL552382 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562822 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL552382 | — | IC50 | = | 15000.0 | nM | 4.82 |