Assay Detail
Binding
CHEMBL1054355
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Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Macrophage migration inhibitory factor (CHEMBL2085) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.65 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554271 | — | — | 1 | 6.30 |
| CHEMBL550268 | — | — | 1 | 5.70 |
| CHEMBL559951 | — | — | 1 | 4.92 |
| CHEMBL558731 | — | — | 1 | 4.82 |
| CHEMBL554732 | — | — | 1 | 4.82 |
| CHEMBL556512 | — | — | 1 | 4.72 |
| CHEMBL564237 | — | — | 1 | 4.70 |
| CHEMBL559258 | — | — | 1 | 4.60 |
| CHEMBL549864 | — | — | 1 | 4.55 |
| CHEMBL562483 | — | — | 1 | 4.54 |
| CHEMBL556445 | — | — | 1 | 4.54 |
| CHEMBL559125 | — | — | 1 | 4.52 |
| CHEMBL559555 | — | — | 1 | 4.32 |
| CHEMBL549389 | — | — | 1 | 4.31 |
| CHEMBL563301 | — | — | 1 | 4.30 |
| CHEMBL538172 | — | — | 1 | 4.22 |
| CHEMBL565030 | — | — | 1 | 4.22 |
| CHEMBL210858 | — | — | 1 | 4.16 |
| CHEMBL553881 | — | — | 1 | 4.00 |
| CHEMBL554783 | — | — | 1 | - |
| CHEMBL538170 | — | — | 1 | - |
| CHEMBL563186 | — | — | 1 | - |
| CHEMBL557060 | — | — | 1 | - |
| CHEMBL559497 | — | — | 1 | - |
| CHEMBL552426 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554271 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL550268 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL559951 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL558731 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL554732 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL556512 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL564237 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL559258 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL549864 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL562483 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL556445 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL559125 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL559555 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL549389 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL563301 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL538172 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL565030 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL210858 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL553881 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL554783 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL538170 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL563186 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL557060 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL552426 | — | IC50 | > | 100000.0 | nM | - |