Assay Detail
Binding
CHEMBL1054709
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Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.21 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559034 | — | — | 1 | 9.62 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 8.42 |
| CHEMBL565019 | — | — | 1 | 8.26 |
| CHEMBL557234 | — | — | 1 | 8.20 |
| CHEMBL551594 | — | — | 1 | 8.16 |
| CHEMBL560119 | — | — | 1 | 8.09 |
| CHEMBL569368 | — | — | 1 | 7.92 |
| CHEMBL550587 | — | — | 1 | 7.72 |
| CHEMBL557505 | — | — | 1 | 7.70 |
| CHEMBL551719 | — | — | 1 | 7.68 |
| CHEMBL553472 | — | — | 1 | 7.62 |
| CHEMBL555073 | — | — | 1 | 7.47 |
| CHEMBL557100 | — | — | 1 | 7.42 |
| CHEMBL557506 | — | — | 1 | 7.36 |
| CHEMBL541753 | — | — | 1 | 7.30 |
| CHEMBL558834 | — | — | 1 | 7.26 |
| CHEMBL563921 | — | — | 1 | 7.21 |
| CHEMBL539098 | — | — | 1 | 7.00 |
| CHEMBL562258 | — | — | 1 | 7.00 |
| CHEMBL562182 | — | — | 1 | 6.92 |
| CHEMBL555973 | — | — | 1 | 6.89 |
| CHEMBL551567 | — | — | 1 | 6.80 |
| CHEMBL559470 | — | — | 1 | 6.75 |
| CHEMBL554938 | — | — | 1 | 6.55 |
| CHEMBL557437 | — | — | 1 | 6.54 |
| CHEMBL560719 | — | — | 1 | 6.50 |
| CHEMBL457882 | — | — | 1 | 6.28 |
| CHEMBL553902 | — | — | 1 | 5.77 |
| CHEMBL560215 | — | — | 1 | 5.16 |
| CHEMBL561376 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559034 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL184238 | URB-597 | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL565019 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL557234 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL551594 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL560119 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL569368 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL550587 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL557505 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL551719 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL553472 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL555073 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL557100 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL557506 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL541753 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL558834 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL563921 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL539098 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL562258 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL562182 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL555973 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL551567 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL559470 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL554938 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL557437 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL560719 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL457882 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL553902 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL560215 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL561376 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL541244 | — | IC50 | = | 108000.0 | nM | - |