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Assay Detail

CHEMBL1054713

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FAAH-mediated hydrolysis of [3H]anandamide in rat RBL2H3 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type RBL-2H3
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
Minkkilä A, Myllymäki MJ, Saario SM, Castillo-Melendez JA, Koskinen AM, Fowler CJ, Leppänen J, Nevalainen T.
Eur J Med Chem (2009) 44 : 2994 -3008
PubMed 19232787 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.09 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL569368 1 7.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL569368 IC50 = 82.0 nM 7.09