Assay Detail
Functional
CHEMBL1054907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 9.08 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 9.08 |
| CHEMBL551532 | — | — | 1 | - |
| CHEMBL559486 | — | — | 1 | - |
| CHEMBL559334 | — | — | 1 | - |
| CHEMBL562395 | — | — | 1 | - |
| CHEMBL552012 | — | — | 1 | - |
| CHEMBL561335 | — | — | 1 | - |
| CHEMBL556852 | — | — | 1 | - |
| CHEMBL561743 | — | — | 1 | - |
| CHEMBL550871 | — | — | 1 | - |
| CHEMBL551272 | — | — | 1 | - |
| CHEMBL557253 | — | — | 1 | - |
| CHEMBL562596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL551532 | — | EC50 | - | — | - | |
| CHEMBL559486 | — | EC50 | - | — | - | |
| CHEMBL559334 | — | EC50 | - | — | - | |
| CHEMBL562395 | — | EC50 | - | — | - | |
| CHEMBL552012 | — | EC50 | - | — | - | |
| CHEMBL561335 | — | EC50 | - | — | - | |
| CHEMBL556852 | — | EC50 | - | — | - | |
| CHEMBL561743 | — | EC50 | - | — | - | |
| CHEMBL550871 | — | EC50 | - | — | - | |
| CHEMBL551272 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL557253 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL562596 | — | EC50 | - | — | - |