Assay Detail
Functional
CHEMBL1055016
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Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically evoked contraction
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 8 | - | - |
| IC50 | 6 | 8.09 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540972 | — | — | 1 | 9.92 |
| CHEMBL556230 | — | — | 1 | 9.89 |
| CHEMBL551937 | — | — | 1 | 9.59 |
| CHEMBL553221 | — | — | 1 | 7.64 |
| CHEMBL563304 | — | — | 1 | 6.46 |
| CHEMBL559088 | — | — | 1 | 5.04 |
| CHEMBL539386 | — | — | 1 | - |
| CHEMBL564083 | — | — | 1 | - |
| CHEMBL554838 | — | — | 1 | - |
| CHEMBL538699 | — | — | 1 | - |
| CHEMBL538384 | — | — | 1 | - |
| CHEMBL557346 | — | — | 1 | - |
| CHEMBL553461 | — | — | 1 | - |
| CHEMBL540724 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540972 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL556230 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL551937 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL553221 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL563304 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL559088 | — | IC50 | = | 9049.0 | nM | 5.04 |
| CHEMBL539386 | — | Activity | - | — | - | |
| CHEMBL564083 | — | Activity | - | — | - | |
| CHEMBL554838 | — | Activity | - | — | - | |
| CHEMBL538699 | — | Activity | - | — | - | |
| CHEMBL538384 | — | Activity | - | — | - | |
| CHEMBL557346 | — | Activity | - | — | - | |
| CHEMBL553461 | — | Activity | - | — | - | |
| CHEMBL540724 | — | Activity | - | — | - |